Researchers at Colorado State University have developed an enhanced tissue-staining technique called Amplified Immunohistochemistry (AMP-IHC) that reveals hidden disease-causing prions while preserving clear cellular structures. By combining standard antibody staining with catalytic signal amplification, AMP-IHC drastically improves visual signal intensity in low-burden tissue samples. This increased sensitivity enhances detection of prions within lymphoid follicles, allowing diagnosticians to identify and quantify infected follicles more effectively, particularly in tissues with minimal prion accumulation or during early stages of Chronic Wasting Disease (CWD). The technique also enabled scientists to detect CWD prions within uterine glands at the maternal-fetal interface, providing direct visual evidence that the disease can be transmitted in utero from mother to offspring. Because AMP-IHC integrates seamlessly into existing diagnostic laboratory workflows, it has the potential to strengthen CWD surveillance, improve diagnostic confidence, and advance research into disease pathogenesis and transmission.
Researchers at Colorado State University have developed an advanced AI software tool, FREE-Graze™, that automatically builds optimized seasonal grazing plans for livestock. By combining satellite imaging, climate data, and plant biomass metrics, the system predicts where forage is most nutritious while accounting for critical ranch needs like terrain, water access, and protected areas. An evolutionary algorithm compares thousands of pasture shapes, rotation dates, and herd sizes to ensure animals receive top-tier nutrition without damaging the land. These dynamic boundaries and adaptive schedules can then be transmitted directly to GPS-enabled virtual fencing collars worn by the herd.
Researchers at Colorado State University have developed a proprietary algorithmic method to identify specific molecular inhibitors that prevent crude oil from clogging pipelines. Asphaltene buildup currently threatens more than 72,000 miles of U.S. pipelines, causing massive economic losses and environmental risks during cleanup. Unlike traditional methods that only clean up existing blocks, this technology targets the root cause by stopping oil molecules from sticking together in the first place. By finding the perfect natural or synthetic inhibitor for specific oil types, this tool keeps pipelines operating safely and efficiently.
Researchers at Colorado State University, University of Colorado Boulder, and University of Michigan have developed a system and method to find and fix hidden performance flaws in next-generation, ultra-thin semiconductor materials. A hyperspectral imaging unit paired with an optical microscope can show how electrical charges alter the material’s underlying energy levels. The results can pinpoint exact spots where the material’s electrical flow is weak or uneven, allowing for a precise, targeted treatment to those flawed areas, and ensuring the entire microchip operates smoothly and reliably.
Researchers at Colorado State University have developed a hybrid power generation system that combines fuel cells and traditional engines to produce highly efficient electricity. The system features a built-in carbon capture unit that removes greenhouse gases directly from the fuel cell’s exhaust. By stripping away carbon dioxide and water vapor, it creates a clean, hydrogen-rich gas to power an internal combustion engine. This integrated approach allows the engine to run cleanly while generating extra electricity to power the carbon capture process itself.
Researchers at Colorado State University have developed a way to build stronger and more versatile hydrogels; flexible materials used in advanced medical treatments. By clustering chemical “anchors” closely together at the ends of polymer chains, this technique mimics binding tricks found in nature. This arrangement allows the material to become tougher and more heat-resistant. This innovation opens the door to highly customizable materials that can mimic and adapt to the human body or changing temperatures.
Researchers at CSU and University of Minnesota have developed a DNA genotyping assay that identifies the presence of Palmer amaranth seeds in a mixture of seeds, for the purpose of detecting noxious weed seed contamination. The test can be used by seed producers to determine if their seed may be sold in locations were Palmer amaranth (Ameranthus palmeri) is a prohibited noxious weed, and they must certify their clean seed.
Researchers at Colorado State University have developed a newly identified genetic trait that allows plants to resist widely used auxin herbicides like 2,4-D and dicamba. This trait works by altering how plants detect and respond to these chemicals, allowing them to survive treatment. The mutation has been shown to function in multiple plant species without harming growth or health. It can also be introduced into crops using gene editing without creating transgenic plants. This discovery creates a new path for improving weed control while protecting crop yields.
Researchers at Colorado State University have created ARMOR, a new system that significantly improves how we pinpoint locations indoors using Wi-Fi. ARMOR is engineered to deliver accurate location tracking even in challenging conditions: 1) it handles Wi-Fi signal distortions caused by different mobile devices, 2) it adapts to distortions in Wi-Fi signals over time due to human movement or furniture rearrangement, and 3) it defends against the often-overlooked risk of cyber-attacks designed to mislead indoor localization systems. ARMOR features a dual-AI architecture: the first AI model performs real-time location estimation, while a second AI model continuously monitors the system’s integrity, detecting errors and applying corrections on the fly. This approach ensures reliable and safe indoor localization all in a lightweight package that can be deployed on smartphones.
Researchers at Colorado State University Pueblo have developed a rapid vegetation identification technique for onsite use. The method uses a molecular tag that produces a visible color change to distinguish between different cannabis types. It enables quick, field-based decisions with optional lab confirmation for added accuracy. The technology supports compliance, traceability, and enforcement across regulated markets.
Researchers at Colorado State University are developing a multi-barreled, rapid-fire device known as a Vortex Gatling Cannon. This innovative system emits a rapid sequence of powerful vortex rings over long distances. The device is powered by low-cost, easily obtainable gases and requires very little electricity to operate. Initial tests have successfully demonstrated its ability to knock over objects and disrupt targets at a distance.
Researchers at Colorado State University and University of Denver have developed a polyurea-coated polymer-matrix-composite panel for impact protection of critical power grid assets, especially large power transformer (LPT) tanks. In simulations, adding a 3 mm polyurea coating to selected 10.8 mm composite laminates, arrested a 400 m/s steel projectile while reducing required thickness, mass, and cost relative to comparable uncoated designs. The technology is especially attractive where utilities need lighter protective structures than conventional steel-based solutions.