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Prevent Costly Crude Oil Clogs

A Smart Way to Keep Pipelines Flowing

At a Glance

Researchers at Colorado State University have developed a proprietary algorithmic method to identify specific molecular inhibitors that prevent crude oil from clogging pipelines. Asphaltene buildup currently threatens more than 72,000 miles of U.S. pipelines, causing massive economic losses and environmental risks during cleanup. Unlike traditional methods that only clean up existing blocks, this technology targets the root cause by stopping oil molecules from sticking together in the first place. By finding the perfect natural or synthetic inhibitor for specific oil types, this tool keeps pipelines operating safely and efficiently.

Background

Asphaltenes are heavy, complex macromolecules found in crude oil that readily aggregate and deposit onto solid surfaces, severely restricting fluid flow. While the petroleum industry spends billions of dollars annually on reactive measures, such as mechanical equipment replacement, pulse pressurization, and post-clog chemical flushes, these methods only address existing blockages rather than preventing them. A proactive solution has historically been difficult to achieve due to the chemical complexity and variability of asphaltenes across different oil reserves. By pairing specific crude compositions with targeted inhibitors, this technology shifts the paradigm from expensive remediation to active prevention.

Overview

This patented technology uses proprietary algorithms to identify the most effective chemical inhibitors for specific oil wells. The algorithm can select both natural compounds already present in the crude oil or synthetic additives. Asphaltenes are highly prone to clumping when temperature or pressure changes occur during transport. By analyzing the unique chemical profile of a crude oil source, the software predicts which inhibitors or molecular combinations will keep these heavy components dissolved.

This precise molecular prevention directly addresses the massive scale of the pipeline problem. It targets the prevention of clogs across the 72,000 miles of active U.S. lines without relying solely on harsh, external chemicals. Instead, by identifying and utilizing natural components already in the crude, operators can maintain optimal flow rates. This advanced approach avoids the immense costs and environmental hazards of emergency shutdowns and chemical cleanups.

Figure 1. A systematics set of model asphaltenes and resins were designed to investigate the molecular features that affect the initial stages of asphaltene precipitation.
Figure 2. A comparative cross-section of a crude oil pipeline demonstrating how CSU’s aggregation deterrent technology prevents heavy asphaltene macromolecules from clumping (left) and maintains a smooth, continuous flow of dispersed molecules (right).

Benefits

• Preventing asphaltene deposition directly boosts the overall flow and transport efficiency of pipeline networks
• Stops asphaltene clumping at the molecular level before physical blockages can form
• Lowers the risk of sudden pipeline blockages and costly maintenance downtime
• Operators can greatly reduce their reliance on harsh chemical flushes and costly cleanups
• Uses natural oil components to reduce the need for external chemical treatments

Applications

• Upstream oil extraction and downhole production fields
• Midstream crude oil transport pipelines and storage networks
• Flow assurance software integration and engineering consulting
• Chemical manufacturing for targeted oilfield additives
• Oil refinery intake systems and pre-treatment processing

Publications

M. Derakhshani-Molayouselfi et al, (2020) “Deterring effect of resins on the aggregation of asphaltenes in n-Heptane.” Energy & Fuels. https://doi.org/10.1021/acs.energyfuels.0c03067

M. Derakhshani-Molayouselfi et al, (2018) “The effect of resins on the aggregation behavior of asphaltenes.” Bulletin of the American Physical Society. http://meetings.aps.org/link/BAPS.2018.MAR.L02.8

Last Updated: August 2026
A large, green metal pipeline elevated on concrete piers stretches across a grassy mountain valley toward rugged alpine peaks in the background.
Opportunity

Available for Exclusive Licensing
TRL: 3

IP Status

US 11,427,766

Inventors

Mortaza Derakhshani Molayouselfi
Martin McCullagh

Reference Number
19-056
Licensing Manager

Jessy McGowan
Jessy.McGowan@colostate.edu
970-491-7100

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