Synthesis and Characterization of Vanadium (IV/V) Citrate Complexes

Influential in the Treatment of Cancer and Diabetes

At a Glance

Researchers at Colorado State University have synthesized more stable vanadium citrate complexes. These novel complexes exhibit better stability at pH ranges similar to in-vivo pH ranges, indicating the complexes can be used for direct intratumoral injections for cancer treatment. The vanadium complexes have a capacity to and promote anti-tumor immunity simultaneously. Therefore, these vanadium citrate complexes are particularly useful when used in conjunction with oncolytic viruses (OVs), as they improve the replication and spread of oncolytic RNA viruses while simultaneously enhancing immune stimulation.

Background

Currently, oncolytic viruses are typically delivered intratumorally in patients. The first approved OV product in North America and Europe, Imlygic, is administered in multiple superficial cancerous lesions in the context of treating advanced melanoma. Intravenous delivery of OVs still remains a hurdle, however, as substantial amounts of virus are either 1) captured by sink organs like the liver and lungs, 2) neutralized by blood and immune cells, or 3) hindered by poor vascularization and other tumor microenvironment-associated barriers.

Until such hurdles are overcome to allow for effective systemic delivery of OVs, there remains a significant need for methods to improve the effectiveness and efficaciousness of OVs delivered intratumorally, in such a way that would not be difficult for clinicians to administer.

Overview

The novel vanadium citrate complexes have been formulated to effectively deliver vanadium ions and remain stable in tumor microenvironments. The complexes have also been incorporated into a single formulation with oncolytic viruses, thus enabling a single injection intratumorally to treat cancer and reduce side effects to nearby

Methods are proprietary, please contact our office for more information!

Benefits

  • Novel complex enhances the stability of vanadium in a solution
  • Reduced toxicity and less hazardous material used
  • Stable formulation allows for widespread use
  • Synergistic effect with oncolytic viruses

Applications

  • Cancer treatment
  • Diabetes treatment
Last Updated: February 2022
Cancer treatment
Opportunity

Available for Licensing
TRL: 3

IP Status

US Patent PendingĀ 
CA Patent Pending

Inventors

Debbie Crans
Heide Murakami
Kateryna Kostenkova

Reference Number
2021-044
Licensing Manager

Steve Foster
Steve.Foster@colostate.edu
970-491-7100