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The Reproductive Trail™

Exploring the fertility frontier through gameplay

At a Glance

Researchers at Colorado State University have developed a board game that simulates the journey of sperm through the female reproductive tract. Players progress through anatomical regions by answering concept-based questions tied to reproductive physiology. The game integrates question cards and event-based challenges to reinforce learning in an interactive, hands-on format. It is designed to enhance engagement and comprehension in large lecture settings where lab access may be limited. 

Background

Reproductive physiology involves multi-step biological processes that span molecular, cellular, and anatomical scales, making it difficult for students to fully grasp through lectures alone. Traditional instruction often emphasizes memorization rather than applied understanding, which can limit long-term retention. At the same time, many institutions face constraints that reduce opportunities for lab-based or experiential learning. This creates a need for accessible, interactive teaching tools that promote active participation and deeper conceptual learning. This board game addresses that gap by translating abstract physiological processes into a structured, collaborative experience. 

Overview

The board game, The Reproductive Trail™, models the progression of sperm from deposition to fertilization within the female reproductive tract. Players move across a board representing anatomical regions such as the cervix, uterus, and oviduct by correctly answering questions associated with each stage. The game includes multiple decks of cards, including question cards that assess understanding of key concepts and event cards that introduce biologically relevant challenges or advantages. Gameplay reflects real physiological barriers and supportive mechanisms, such as capacitation and transport dynamics, creating a realistic progression system. The objective is to reach the ovary and successfully answer a final fertilization question, reinforcing cumulative understanding of the material. 

Figure 1. Game components of The Reproductive Trail displayed during setup, showing anatomical game board, colorful animal-themed question decks, and challenge cards designed to reinforce concepts in reproductive physiology through interactive play.
Figure 2. Close-up views of The Reproductive Trail board game. (a) The anatomical game board maps the journey of sperm through the female reproductive tract from deposition to fertilization. (b) Color-coded question cards test players’ understanding of key reproductive physiology concepts such as capacitation and zygote formation, reinforcing learning through active gameplay.

Benefits

  • Promotes active, hands-on learning 
  • Enhances student engagement and participation 
  • Supports retention of complex physiological concepts 
  • Encourages collaborative and peer-based learning 
  • Provides an accessible alternative to lab-based instruction 
  • Reinforces real biological processes through simulation 
  • Suitable for large lecture environments 
  • Adaptable for classroom and training use 

Applications

  • Undergraduate and high school courses in reproductive physiology and anatomy 
  • Large lecture STEM courses with limited laboratory access 
  • Supplemental instructional tool for biology and life science curricula 
  • Educational training in reproductive health and animal science fields 
  • Outreach and informal science education programs 
Last Updated: June 2026
Hands holding educational game cards over a printed game board illustrating the female reproductive tract, with colorful decks of anatomy-specific cards arranged around the board.
Opportunity

Available for Exclusive Licensing
TRL: 7

IP Status

Copyright and Trademark

Inventors

Caitlin Cadaret

Reference Number
2025-057
Licensing Manager

Jessy McGowan
Jessy.McGowan@colostate.edu
970-491-7100

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