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A Pocket-Sized Device for Fast, Affordable Disease Detection

CREXENS: A handheld electrochemical sensing platform

At a Glance

Researchers at Colorado State University have developed a low-cost, portable device for quickly detecting diseases. The platform uses electrical signals to identify harmful pathogens with high accuracy. It connects to a smartphone app, making testing simple and accessible. Small, reliable, and easy to use; it enables testing in clinics, homes, and field settings. 

Background

Early disease detection is critical for effective treatment, but many diagnostic tools are expensive and require laboratory facilities. Techniques like PCR offer high accuracy but are not well suited for using outside of controlled environments. Electrochemical sensing provides a simpler and more portable alternative, though many existing systems lack ease of use and adaptability. This platform addresses these limitations by combining accuracy, affordability, and user-friendly design. 

Overview

The CREXENS™ platform is a handheld diagnostic device that uses electrochemical impedance spectroscopy (EIS) to detect pathogens by measuring changes in a sample’s electrical properties. It integrates sensors, onboard data processing, and wireless communication with a smartphone app for real-time analysis and display. The system automatically reduces signal noise and adjusts measurement settings to improve performance across different testing conditions. 

The device operates across a wide frequency range, enabling precise detection with an error of approximately 2.6%, which is comparable to larger laboratory instruments. Its modular design supports different add-on components for enhanced performance or functionality. With a production cost under $50, the platform combines strong analytical capability with portability, making it suitable for both controlled and real-world environments. 

Figure 1. CREXENS™ device setup alongside smartphone app interface displaying real-time measurement data.
Figure 2. Printed circuit board (PCB) implementation of the CREXENS™ platform: (a) base unit, (b) low-noise add-on module, (c) quad-channel add-on module, (d) high-performance add-on module, (e) base unit with high-performance module, (f) base unit with low-noise module, and (g) base unit with quad-channel module.

Benefits

  • Low production cost, enabling broad accessibility 
  • Compact and portable for use outside traditional labs 
  • Simple smartphone-based interface for easy operation 
  • High accuracy with low measurement error (~2.6%) 
  • Flexible design adaptable to different sensing needs 
  • Reliable performance in both lab and field conditions 

Applications

  • Point-of-care testing for infectious diseases 
  • At-home or remote health monitoring 
  • Rapid screening during outbreaks or in low-resource settings 
  • Environmental testing for contaminants or pathogens 
  • Educational platforms for teaching electrochemical sensing 

Publications

Yang, et al, (2019) “CREXENS: An expandable general-purpose electrochemical analyzer.” Mountain Scholar. https://mountainscholar.org/bitstream/10217/199751/1/Yang_colostate_0053A_15717.pdf

Yang, et al (2017) “A handheld electrochemical sensing platform for point-of-care diagnostic applications.” 2017 IEEE Biomedical Circuits and Systems Conference. https://doi.org/10.1109/BIOCAS.2017.8325052

Yang, et al (2017) “A portable biosensor system for pathogen diagnostic applications.” Grad Student Showcase poster. Mountain Scholar. https://hdl.handle.net/10217/184801

Yang, et al (2016) “A compact signal generation and acquisition circuit for electrochemical impedance spectroscopy.” 2016 IEEE Biomedical Circuits and Systems Conference. https://doi.org/10.1109/BioCAS.2016.7833781

Last Updated: April 2026
Top-down view of the CREXENS™ printed circuit board layout showing red components and white and blue wiring traces on a black background, measuring about 93 by 40 millimeters.
Opportunity

Available for Exclusive Licensing
TRL: 5

IP Status

US 11,346,805

Inventors

Thomas Chen
Lang Yang

Reference Number
17-045
Licensing Manager

Jessy McGowan
Jessy.McGowan@colostate.edu
970-491-7100

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