Researchers at Colorado State University have fabricated antibiotic-encapsulated PLGA nanoparticles that shows uniform porous nanostructures, time-dependent drug release and particle degradation profiles, and good antimicrobial performance. Gentamicin sulfate was chosen as the antibiotic encapsulated in the PLGA nanoparticles due to the drugs broad-spectrum properties against both gram positive and gram-negative bacteria. The results show incorporation of PLGA nanoparticles as a platform where antibiotics can be encapsulated for developing efficient drug delivery systems.
