Superhemophobic Surfaces with Improved Hemocompatibility

At a Glance

Researchers at Colorado State University have developed superhemophobic surfaces (surfaces that are extremely repellent to blood). Specifically, a fluorinated titanium surface having a textured morphology of either a nanotube or nanoflower array.

Overview

Titanium based implants have created a great deal of attention for their biocompatibility with many different tissues within the human body. However, when these implants come into contact with blood, platelet adhesion and activation occur, which may lead to further thrombosis and sometimes failure of these implants. It is well known that blood platelet adhesion and activation can be tailored by tuning the chemistry and texture of surfaces.

One strategy that has been recently receiving attention is improving hemocompatibility (e.g., reduced platelet adhesion and activation) by employing superhydrophobic surfaces (i.e., surfaces that are extremely repellent to water). Superhydrophobic surfaces display very high contact angles, typically >150° and very low roll off angles (i.e., the minimum angle by which the surface must be tilted relative to the horizontal for the droplet to roll off), typically <10° with water (a liquid with high surface tension, γlv=72.1 mN m−1). However, superhydrophobic surfaces may not display high contact angles and more importantly very low roll off angles with blood (a liquid with relatively lower surface tension, γlv≈56 mN m−1). While there are a few studies investigating the hemocompatibility of superhydrophobic titania surfaces, it is not clear from the reports whether they are superhemophobic or not.

Accordingly, the fabrication of improved hemocompatible, superhemophobic medical implants would be beneficial to the medical field.

Benefits

  • Significantly reduces platelet adhesion and activation
  • Formation of blood clot on superhemophobic surface is negligible

Applications

  • Medical Devices/Implants: vascular stents, IVC filters, and cardiac occlusion devices
Last Updated: August 2022
Opportunity

Available for Licensing

IP Status

US Patent: US 2018/0303981

Inventors

Arun Kota
Ketul Popat
Lakshmi Prasad

Reference Number
17-049
Licensing Manager

Jessy McGowan
Jessy.McGowan@colostate.edu
970-491-7100