Limb Sparing in Dogs

Personalized Endoprostheses and Cutting Guides

At a Glance

Issued from the collaboration between 3 top institutions in North America, 3D-printed endoprostheses (Fig. 1) and a custom cutting guide have been developed and commercialized for an efficient limb sparing at distal radius or proximal humerus. The patient-specific implant is contoured to an individual geometry to fit perfectly for a better withstanding of the loads transmitted through the limb.  It allows the surgical time to be significantly decreased, thus reducing the infection rates.  The 3D-printing also facilitates controlled surface texturing of endoprosthesis and the subsequent bioactivation using local delivery of chemotherapeutics.   Coupled with the implant, the personalized cutting guide allows the osteotomy to be performed precisely at the location prescribed by the surgeon, providing an ideal interface between the implant and the remaining bone.

Background

Osteosarcoma accounts for approximately 85% of bone tumors in dogs and ~ 10,000 new diagnostics are made each year in the United States. The distal radius/ulna is the most common site of the primary tumor.

Limb sparing in combination with arthrodesis represents a common approach to treat this condition. During limb sparing surgery, the affected bone portion is removed en bloc and the bone defect is spanned. This new technology and approach contrast with existing limb sparing techniques associated with post-surgery complication rates around 75%, rendering limb imputation the only available surgical treatment. In addition of having very few complications, this innovative solution is characterized by a very limited period of convalescence, and a very good walking ability of the animal right after the operation.

Overview

A clinical trial at Colorado State University was successfully conducted on five dogs suffering from radius osteosarcoma.

The technology is now at a commercial stage. Since last year, several endoprostheses have been sold and implemented in commercial mode with a pool of veterinarians promoting the implants to their customers in US and Canada.

Benefits

  • Guarantees adequate biomechanical functionality of the spared limb
  • Lower risk of implant/bone failure
  • Reduced surgical time
  • Lower infection risk
  • Reduced risk of tumor recurrence
  • Improves patient’s quality of life

Applications

  • Animal prosthesis
Last Updated: February 2023
Veterinarian and Dog
Opportunity

Available for Licensing
TRL: 9

Inventors

Bernard Seguin

Reference Number
17-043
Licensing Manager

Steve Foster
Steve.Foster@colostate.edu
970-491-7100