Monoclonal Antibodies Targeting SARS-VOC-2 Nucleocapsid Protein

Coronavirus nucleocapsid protein plays a key role in coating the viral RNA genome during virion formation, and overall pathogenesis. Additionally, the nucleocapsid protein has been used as a diagnostic marker for active coronavirus infection. There are very few antibody reagents currently available that are specific for SARS-CoV-2 nucleocapsid, as most monoclonal antibodies that are commercially available were generated against SARS-CoV nucleocapsid protein and are cross-reactive for SARS-CoV-2 nucleocapsid.   There is a significant need for new antibodies to be produced with increased specificity and utility for detecting SARS-CoV-2 nucleocapsid protein for both the research community and the necessity to develop therapeutics.